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Anavar, known scientifically as Oxandrolone, was first developed in the 1960s during efforts to design synthetic molecules with a favorable anabolic-to-androgenic profile. Its structure, derived from dihydrotestosterone, incorporates a 2-oxa substitution that distinguishes it within its class and contributes to its functional selectivity. Over the decades, Anavar has been examined in controlled research environments for its receptor interaction patterns, metabolic stability, and structural modifications that influence anabolic signaling. Scientific literature often highlights its predictable behavior under analytical methods such as HPLC, NMR, and mass spectrometry, which confirm its identity and purity in laboratory settings. This history establishes Anavar as a consistent reference compound in studies exploring structure–activity relationships among DHT-based derivatives.